Pharmacodynamic gene polymorphism and adverse drug reactionsthen applying antipsychotic drugs
https://doi.org/10.14341/WJPM9265
Abstract
Application of antipsychotic drugs of both the first and subsequent generations quite often causes adverse side effects, which can reduce the compliance to the treatment of patients, reducing their quality of life. One of the most serious NLRs that occur during the period of application of antipsychotic disorders in patients are extrapyramidal disorders (acute dystonia, dyskinesia), malignant neuroleptic syndrome and tardive dyskinesia. During the year of therapy with the use of antipsychotic drugs of the first generation, signs of late dyskinesia appear in 3 to 5% of patients, and in elderly patients this figure is 5 times higher.
The achievement of recent years in medicine is the application of the pharmacogenetic approach for predicting the patient’s individual response to taking the drug.
Recent advances in medicine is the practice of pharmacogenetic approach to predict the patient’s individual response to receiving the drug. The pharmacogenetic approach to the prescription of medicines is based on the study of the effect of polymorphism of genes encoding the synthesis of isoenzymes of biotransformation and transport of xenobiotics, as well as the synthesis of elements responsible for the pharmacodynamic component.
In this article, we will attempt to describe the main adverse side effects arising from the use of antipsychotic drugs, as well as consider pharmacogenetic aspects of their appearance, to summarize the relevant information currently available. arisingfrom the use of antipsychotic drugs, as well as consider pharmacogenetic aspects of their appearance, to summarize the relevant information currently available.
About the Authors
Mikhail S. ZastrozhinRussian Medical Academy of Continuous Professional Education; Moscow Research and Practical Centre for Narcology of the Department of Public Health
Russian Federation
MD, PhD
Dmitry A. Sychev
Russian Medical Academy of Continuous Professional Education
Russian Federation
MD, PhD, Professor
Elena A. Grishina
Russian Medical Academy of Continuous Professional Education
Russian Federation
MD, PhD, professor associate
Ludmila M. Savchenko
Russian Medical Academy of Continuous Professional Education
Russian Federation
MD, PhD, professor associate
Evgeny A. Bryun
Russian Medical Academy of Continuous Professional Education; Moscow Research and Practical Centre for Narcology of the Department of Public Health
Russian Federation
MD, PhD, professor
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Review
For citations:
Zastrozhin M.S., Sychev D.A., Grishina E.A., Savchenko L.M., Bryun E.A. Pharmacodynamic gene polymorphism and adverse drug reactionsthen applying antipsychotic drugs. World Journal of Personalized Medicine. 2017;1(1):5-12. (In Russ.) https://doi.org/10.14341/WJPM9265